Analysis of ranked gene tree probability distributions under the coalescent process for detecting anomaly zones

In phylogenetic studies, gene trees are used to reconstruct species tree. Under the multispecies coalescent model, gene trees topologies may differ from that of species trees. The incorrect gene tree topology (one that does not match the species tree) that is more probable than the correct one is termed anomalous gene tree (AGT). Species trees that can generate such AGTs are said to be in the anomaly zone (AZ). In this region, the method of choosing the most common gene tree as the estimate of the species tree will be inconsistent and will converge to an incorrect species tree when the number of loci increases. In this work, we focus on unranked and ranked trees. The difference between these two is that the ranked gene tree not only depicts the topological relationship among gene lineages but also the sequence in which the lineages coalesce (join). In our project, software which allows computing probabilities of ranked gene trees given a species tree under coalescent process was developed to study how the parameters of the species tree simulated under a birth-death process can affect the AZ. Since some combinations of topologies and branch lengths in a species tree can produce AGTs, we compute the probabilities of ranked and unranked gene trees for the entire distribution of 5-8 taxon species trees to find a set of branch length space in which a species tree has either unranked AGTs, ranked AGTs, or both. Because the number of all possible tree topologies grows exponentially with the number of species, we propose some heuristic approaches for inferring large trees. Studying the properties of AGTs, as well as a connection between ranked and unranked anomaly zones, will help to find strategies for solving the problem of AGTs during phylogenetic inference

Maximum likelihood estimation of species trees and anomaly zone detection using ranked gene trees

A phylogenetic tree represents the evolutionary relationships among a set of organisms. Gene trees can be used to reconstruct phylogenetic trees. The methods in this dissertation focus on the gene tree topologies with emphasis on ranked gene tree topologies. A ranked tree depicts the order in which nodes appear in the tree together with topological relationships among gene lineages. One challenge that arises during phylogenetic inference is the existence of the anomaly zones, the regions of branch-length space in the species tree that can produce gene trees that have topologies differing from the species tree topology but are more probable than the gene tree matching the species tree. In this work, we show how the parameters of a constant-rate birth-death process used to simulate species trees affect the probability that the species tree lies in the anomaly zone. We prove that the probability that a species tree is in an anomaly zone approaches 1 as the number of species and the birth rate go to infinity in a pure birth process. We propose a heuristic approach to infer whether species trees lie in the different types of anomaly zones trees when it is intractable to compute the entire distribution of gene tree topologies. In this dissertation, we develop the first maximum likelihood (ML) method that infers a species tree from the ranked gene trees. We introduce the software PRANC, which can compute the probabilities of ranked gene trees under the coalescent process and infer an ML species tree. We propose methods to estimate a starting tree to be able to locate the ML species tree quickly. To illustrate the methods proposed, we analyze two experimental studies of skinks and gibbons

Розробка принципів управління процесами безперервного розливання сплавів з використанням магнітодинамічного обладнання

A new principle to control the temperature and mass flow rate of metal melt at its continuous casting has been proposed. It has been established that such control can be executed based on continuous monitoring of the mass of a liquid alloy in casting and metallurgical assemblies and at appropriate adjustment by the equipment systems. Using electromagnetic fields and magnetohydrodynamic (MHD) factors to influence a liquid-metal environment is an effective means to ensure the required technological and technical-economic indicators for the process of continuous casting. We have proposed an appropriate principal structural-functional circuit for the automated control system (ACS) over the process of continuous casting of alloys, based on the application of a magnetodynamic tundish (MD-T) and a magneto-weighting system. Their basic design features and functional capabilities have been defined that are related to the processes of continuous casting, compared both with existing equipment and systems for similar purposes. It has been proposed to implement MD-T in the form of a two-chamber assembly, which separates the functions of receiving the melt from a steel-casting ladle, heating the liquid metal, releasing it into the crystallizer of a continuous casting machine (CCM). Stabilization of the flow rate mode of casting, including low-head, is achieved by permanently controlling the mass of melt in the system and by tracking its level in the release chamber of MD-T and in the crystallizer of CCM.The devised technique and created assemblies, the system, as well as auxiliary devices, would make it possible to significantly improve modern technologies of continuous castingПредложен новый принцип управления температурой и массовым расходом металлического расплава при его непрерывной разливке. Установлено, что такое управление может осуществляться на основе постоянного контроля массы жидкого сплава в литейных и металлургических агрегатах и соответствующего регулирования системами оборудования. Использование для влияния на жидкометаллическую среду электромагнитных полей и магнитогидродинамических (МГД) факторов является эффективным средством обеспечения необходимых технологических и технико-экономических показателей процесса непрерывной разливки. Предложена соответствующая принципиальная конструктивно-функциональная схема системы автоматического управления (САУ) процессом непрерывной разливки сплавов, в основу которой положено применение магнитодинамического промежуточного ковша (МД-ПК) и магнитовесовой системы. Определены их основные конструктивные особенности и функциональные возможности применительно к процессам непрерывной разливки как по сравнению с существующим оборудованием, так и с системами аналогичного назначения. Предлагается реализовать МД-ПК в виде двухкамерного агрегата, в котором разделены функции приема расплава из сталеразливочного ковша, нагрева жидкого металла, выдачи его в кристаллизатор машины непрерывного литья заготовок (МНЛЗ). Стабилизация расходного режима разливки, в том числе малонапорного, осуществляется за счет постоянного контроля массы расплава в системе и отслеживания его уровня в выпускной камере МД-ПК и кристаллизаторе МНЛЗ.Разработанный способ и создаваемые агрегаты, система и вспомогательные устройства позволят существенно усовершенствовать современные технологии непрерывного литьяЗапропоновано новий принцип управління температурою та масовою витратою металевого розплаву при його безперервному розливанні. Встановлено, що таке управління може здійснюватися на основі постійного контролю маси рідкого сплаву в ливарних та металургійних агрегатах і відповідного регулювання системами обладнання. Використання для впливу на рідкометалеве середовище електромагнітних полів та магнітогідродинамічних (МГД) чинників є ефективним засобом забезпечення необхідних технологічних та техніко-економічних показників процесу безперервного розливання. Запропоновано відповідну принципову конструктивно-функціональну схему системи автоматичного управління (САУ) процесом безперервного розливання сплавів, яка ґрунтується на застосуванні магнітодинамічного проміжного ковша (МД-ПК) і магнітовагової системи.  Визначено їх основні конструктивні особливості та функціональні можливості стосовно до процесів безперервного розливання як у порівнянні з існуючим обладнанням, так і з системами аналогічного призначення. Пропонується реалізувати МД-ПК у вигляді двокамерного агрегату, в якому розділені функції прийому розплаву зі сталерозливного ковша, нагрівання рідкого металу, видачі його у кристалізатор машини безперервного лиття заготівок (МБЛЗ). Стабілізація витратного режиму розливання, у тому числі малонапорного, здійснюється за рахунок постійного контролю маси розплаву в системі та відстеження його рівня у випускній камері МД-ПК і кристалізаторі МБЛЗ.Розроблений спосіб та створювані агрегат, система і допоміжні пристрої дозволять суттєво удосконалити сучасні технології безперервного литт

Розробка принципів управління процесами безперервного розливання сплавів з використанням магнітодинамічного обладнання

A new principle to control the temperature and mass flow rate of metal melt at its continuous casting has been proposed. It has been established that such control can be executed based on continuous monitoring of the mass of a liquid alloy in casting and metallurgical assemblies and at appropriate adjustment by the equipment systems. Using electromagnetic fields and magnetohydrodynamic (MHD) factors to influence a liquid-metal environment is an effective means to ensure the required technological and technical-economic indicators for the process of continuous casting. We have proposed an appropriate principal structural-functional circuit for the automated control system (ACS) over the process of continuous casting of alloys, based on the application of a magnetodynamic tundish (MD-T) and a magneto-weighting system. Their basic design features and functional capabilities have been defined that are related to the processes of continuous casting, compared both with existing equipment and systems for similar purposes. It has been proposed to implement MD-T in the form of a two-chamber assembly, which separates the functions of receiving the melt from a steel-casting ladle, heating the liquid metal, releasing it into the crystallizer of a continuous casting machine (CCM). Stabilization of the flow rate mode of casting, including low-head, is achieved by permanently controlling the mass of melt in the system and by tracking its level in the release chamber of MD-T and in the crystallizer of CCM.The devised technique and created assemblies, the system, as well as auxiliary devices, would make it possible to significantly improve modern technologies of continuous castingПредложен новый принцип управления температурой и массовым расходом металлического расплава при его непрерывной разливке. Установлено, что такое управление может осуществляться на основе постоянного контроля массы жидкого сплава в литейных и металлургических агрегатах и соответствующего регулирования системами оборудования. Использование для влияния на жидкометаллическую среду электромагнитных полей и магнитогидродинамических (МГД) факторов является эффективным средством обеспечения необходимых технологических и технико-экономических показателей процесса непрерывной разливки. Предложена соответствующая принципиальная конструктивно-функциональная схема системы автоматического управления (САУ) процессом непрерывной разливки сплавов, в основу которой положено применение магнитодинамического промежуточного ковша (МД-ПК) и магнитовесовой системы. Определены их основные конструктивные особенности и функциональные возможности применительно к процессам непрерывной разливки как по сравнению с существующим оборудованием, так и с системами аналогичного назначения. Предлагается реализовать МД-ПК в виде двухкамерного агрегата, в котором разделены функции приема расплава из сталеразливочного ковша, нагрева жидкого металла, выдачи его в кристаллизатор машины непрерывного литья заготовок (МНЛЗ). Стабилизация расходного режима разливки, в том числе малонапорного, осуществляется за счет постоянного контроля массы расплава в системе и отслеживания его уровня в выпускной камере МД-ПК и кристаллизаторе МНЛЗ.Разработанный способ и создаваемые агрегаты, система и вспомогательные устройства позволят существенно усовершенствовать современные технологии непрерывного литьяЗапропоновано новий принцип управління температурою та масовою витратою металевого розплаву при його безперервному розливанні. Встановлено, що таке управління може здійснюватися на основі постійного контролю маси рідкого сплаву в ливарних та металургійних агрегатах і відповідного регулювання системами обладнання. Використання для впливу на рідкометалеве середовище електромагнітних полів та магнітогідродинамічних (МГД) чинників є ефективним засобом забезпечення необхідних технологічних та техніко-економічних показників процесу безперервного розливання. Запропоновано відповідну принципову конструктивно-функціональну схему системи автоматичного управління (САУ) процесом безперервного розливання сплавів, яка ґрунтується на застосуванні магнітодинамічного проміжного ковша (МД-ПК) і магнітовагової системи.  Визначено їх основні конструктивні особливості та функціональні можливості стосовно до процесів безперервного розливання як у порівнянні з існуючим обладнанням, так і з системами аналогічного призначення. Пропонується реалізувати МД-ПК у вигляді двокамерного агрегату, в якому розділені функції прийому розплаву зі сталерозливного ковша, нагрівання рідкого металу, видачі його у кристалізатор машини безперервного лиття заготівок (МБЛЗ). Стабілізація витратного режиму розливання, у тому числі малонапорного, здійснюється за рахунок постійного контролю маси розплаву в системі та відстеження його рівня у випускній камері МД-ПК і кристалізаторі МБЛЗ.Розроблений спосіб та створювані агрегат, система і допоміжні пристрої дозволять суттєво удосконалити сучасні технології безперервного литт

Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH

Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding, mature TIM

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network analysis applied to three large-scale transcriptional datasets: we introduce (1) an ImmGen MNP open-source dataset of 337 samples across 26 tissues; (2) a myeloid subset of ImmGen Phase I dataset (202 MNP samples); and (3) a myeloid mouse single-cell RNA sequencing (scRNA-seq) dataset (51,364 cells) assembled based on Tabula Muris Senis. To analyze such large-scale datasets, we develop a network-based computational approach, genes and metabolites (GAM) clustering, for unbiased identification of the key metabolic subnetworks based on transcriptional profiles. We define 9 metabolic subnetworks that encapsulate the metabolic differences within MNP from 38 different tissues. Obtained modules reveal that cholesterol synthesis appears particularly active within the migratory dendritic cells, while glutathione synthesis is essential for cysteinyl leukotriene production by peritoneal and lung macrophages

Marine Strategy Framework Directive - Descriptor 2, Non-Indigenous Species, Delivering solid recommendations for setting threshold values for non-indigenous species pressure on European seas

Marine Non-Indigenous Species (NIS) are animals and plants introduced accidently or deliberately into the European seas, originating from other seas of the globe. About 800 marine non-indigenous species (NIS) currently occur in the European Union national marine waters, several of which have negative impacts on marine ecosystem services and biodiversity. Under the Marine Strategy Framework Directive (MSFD) Descriptor 2 (D2), EU Member States (MSs) need to consider NIS in their marine management strategies. The Descriptor D2 includes one primary criterion (D2C1: new NIS introductions), and two secondary criteria (D2C2 and D2C3). The D2 implementation is characterized by a number of issues and uncertainties which can be applicable to the Descriptor level (e.g. geographical unit of assessment, assessment period, phytoplanktonic, parasitic, oligohaline NIS, etc.), to the primary criterion D2C1 level (e.g. threshold values, cryptogenic, questionable species, etc), and to the secondary criteria D2C2 and D2C3. The current report tackles these issues and provides practical recommendations aiming at a smoother and more efficient implementation of D2 and its criteria at EU level. They constitute a solid operational output which can result in more comparable D2 assessments among MSs and MSFD regions/subregions. When it comes to the policy-side, the current report calls for a number of different categories of NIS to be reported in D2 assessments, pointing the need for the species to be labelled/categorised appropriately in the MSFD reporting by the MSs. These suggestions are proposed to be communicated to the MSFD Working Group of Good Environmental Status (GES) and subsequently to the Marine Strategy Coordination Group (MSCG) of MSFD. Moreover, they can serve as an input for revising the Art. 8 Guidelines

Cellular anatomy of the mouse primary motor cortex.

An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted1. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture

Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part three

From Springer Nature via Jisc Publications Router.Publication status: PublishedHistory: collection 2017-09, epub 2017-09-0

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of IDO in a murine model of gingivitis: predictive and therapeutic potentials Babak Baban, Jun Yao Liu, Xu Qin, Tailing Wang, Mahmood S. Mozaffari A6 Specific diets for personalised treatment of diabetes type 2 Viktoriia V. Bati, Tamara V. Meleshko, Olga B. Levchuk, Nadiya V. Boyko A7 Towards personalized physiotherapeutic approach Joanna Bauer, Ewa Boerner, Halina Podbielska A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu A10 PPPM in cardiovascular medicine in 2015 Hans-Peter Brunner-La Rocca A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak A12 Ultrasound diagnosis for diabetic neuropathy - comparative study Rostyslav V. Bubnov, Tetyana V. Ostapenko A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer John Paul Cauchi A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well? Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov A16 Survey of questionnaires for evaluation of the quality of life in various medical fields Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska A17 Personalized molecular treatment for muscular dystrophies Sebahattin Cirak A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani A21 Mental indicators at young people with attributes hypertension and pre-hypertension Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon? Shantanu Girotra, Olga Golubnitschaja A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch A27 Immunohistochemical assessment of APUD cells in endometriosis Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver A32 The correlation of dietary habits with gingival problems during menstruation Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara A35 Metabolic hallmarks of cancer as targets for a personalized therapy John Ionescu A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva A37 Challenges in diabetic macular edema Tatjana Josifova A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola A39 EPMA initiative for effective organization of medical travel: European concepts and criteria Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja A40 Design and innovation in e-textiles: implications for PPPM Anthony Kent, Tom Fisher, Tilak Dias A41 Biobank in Pilsen as a member of national node BBMRI_CZ Judita Kinkorová, Ondřej Topolčan A42 Big data in personalized medicine: hype and hope Matthias Kohl A43 The 3P approach as the platform of the European Dentistry Department (DPPPD) Anatoly A. Kunin, Natalia S. Moiseeva A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka A47 Targeting "disease signatures" towards personalized healthcare Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin A50 The use of LED radiation in prevention of dental diseases Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren’s syndrome: predictive and personalized treatment potentials Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban A53 Maximal aerobic capacity - important quality marker of health Jaroslav Novák, Milan Štork, Václav Zeman A54 The EMPOWER project: laboratory medicine and Horizon 2020 Wytze P. Oosterhuis, Elvar Theodorsson A55 Personality profile manifestations in patient’s attitude to oral care and adherence to doctor’s prescriptions Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta A57 MCI or early dementia predictive speech based diagnosis techniques Matus Pleva, Jozef Juhar A58 Personalized speech based mobile application for eHealth Matus Pleva, Jozef Juhar A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan A61 Sleep apnea and sleep fragmentation contribute to brain aging Kneginja Richter, Lence Miloseva, Günter Niklewski A62 Personalised approach for sleep disturbances in shift workers Kneginja Richter, Jens Acker, Guenter Niklewski A63 Medical travel and innovative PPPM clusters: new concept of integration Olga Safonicheva, Vincenzo Costigliola A64 Medical travel and women health Olga Safonicheva A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery Maxim Sautin, Janna Sinelnikova, Sergey Suchkov A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany Songül Secer, Stephan von Bandemer A67 Women’s increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine Niva Shapira A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases Aleksandr Shcherbakov, Anatoly A. Kunin, Natalia S. Moiseeva A69 Use of specially treated composites in dentistry to avoid violations of aesthetics Bogdan R. Shumilovich, Zhanna Lipkind, Yulia Vorobieva, Dmitry A. Kunin, Anastasiia V. Sudareva A70 National eHealth system – platform for preventive, predictive and personalized diabetes care Ivica Smokovski, Tatjana Milenkovic A72 The common energy levels of Prof. Szent-Györgyi, the intrinsic chemistry of melanin, and the muscle physiopathology. Implications in the context of Preventive, Predictive, and Personalized Medicine Arturo Solís-Herrera, María del Carmen Arias-Esparza, Sergey Suchkov A73 Plurality and individuality of hepatocellular carcinoma: PPPM perspectives Krishna Chander Sridhar, Olga Golubnitschaja A74 Strategic aspects of higher medical education reforms to secure newer educational platforms for getting biopharma professionals matures Maria Studneva, Sihong Song, James Creeden, Мark Мandrik, Sergey Suchkov A75 Overview of the strategies and activities of the European Federation of Clinical Chemistry and Laboratory Medicine, (EFLM) Elvar Theodorsson, EFLM A76 New spectroscopic techniques for point of care label free diagnostics Syed A. M. Tofail A77 Tumor markers for personalized medicine and oncology - the role of Laboratory Medicine Ondřej Topolčan, Judita Kinkorová, Ondřej Fiala, Marie Karlíková, Šárka Svobodová, Radek Kučera, Radka Fuchsová, Vladislav Třeška, Václav Šimánek, Ladislav Pecen, Jan Šoupal, Štěpán Svačina2 A78 Modern medical terminology (MMT) as a driver of the global educational reforms Evgeniya Tretyak, Maria Studneva, Sergey Suchkov A79 Juvenile hypertension; the relevance of novel predictive, preventive and personalized assessment of its determinants Francesca M. Trovato, G. Fabio Martines, Daniela Brischetto, Daniela Catalano, Giuseppe Musumeci, Guglielmo M. Trovato A80 Proteomarkers Biotech George Th. Tsangaris, Athanasios K. Anagnostopoulos A81 Proteomics and mass spectrometry based non-invasive prenatal testing of fetal health and pregnancy complications George Th. Tsangaris, Athanasios K. Anagnostopoulos A82 Integrated Ecosystem for an Integrated Care model for Heart Failure (HF) patients including related comorbidities (ZENITH) José Verdú, German Gutiérrez, Jordi Rovira, Marta Martinez, Lutz Fleischhacker, Donna Green, Arthur Garson, Elena Tamburini, Stefano Cuomo, Juan Martinez-Leon, Teresa Abrisqueta, Hans-Peter Brunner-La Rocca, Tiny Jaarsma, Teresa Arredondo, Cecilia Vera, Giuseppe Fico, Olga Golubnitschaja, Fernando Arribas, Martina Onderco, Isabel Vara, on behalf of ZENITH consortium A83 Predictive, preventive and personalized medicine in diabetes onset and complication (MOSAIC project) José Verdú, Francesco Sambo, Barbara Di Camillo, Claudio Cobelli, Andrea Facchinetti, Giuseppe Fico, Riccardo Bellazzi, Lucia Sacchi, Arianna Dagliati, Daniele Segnani, Valentina Tibollo, Manuel Ottaviano, Rafael Gabriel, Leif Groop, Jacqueline Postma, Antonio Martinez, Liisa Hakaste, Tiinamaija Tuomi, Konstantia Zarkogianni, on behalf of MOSAIC consortium A84 Possibilities for personalized therapy of diabetes using in vitro screening of insulin and oral hypoglycemic agents Igor Volchek, Nina Pototskaya, Andrey Petrov A85 The innovative technology for personalized therapy of human diseases based on in vitro drug screening Igor Volchek, Nadezhda Pototskaya, Andrey Petrov A86 Bone destruction and temporomandibular joint: predictive markers, pathogenetic aspects and quality of life Ülle Voog-Oras, Oksana Jagur, Edvitar Leibur, Priit Niibo, Triin Jagomägi, Minh Son Nguyen, Chris Pruunsild, Dagmar Piikov, Mare Saag A87 Sub-optimal health management – global vision for concepts in medical travel Wei Wang A88 Sub-optimal health management: synergic PPPM-TCAM approach Wei Wang A89 Innovative technologies for minimal invasive diagnostics Andreas Weinhäusel, Walter Pulverer, Matthias Wielscher, Manuela Hofner, Christa Noehammer, Regina Soldo, Peter Hettegger, Istvan Gyurjan, Ronald Kulovics, Silvia Schönthaler, Gabriel Beikircher, Albert Kriegner, Stephan Pabinger, Klemens Vierlinger A90 Rare disease diobanks for personalized medicine Ayşe Yüzbaşıoğlu, Meral Özgüç, Member of EuroBioBank - European Network of DNA, Cell and Tissue Banks for Rare Disease